HDAC6 antibody (C-Term)

Catalog No. ABIN2780739

This Rabbit Polyclonal antibody specifically detects HDAC6 in WB, IHC and ChIP. It exhibits reactivity toward Human, Mouse, Rat, Pig, Rabbit, Dog, Guinea Pig, Cow and Horse.

Quick Overview for HDAC6 antibody (C-Term) (ABIN2780739)

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Dog, Guinea Pig, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Product Details anti-HDAC6 Antibody

Binding Specificity: C-Term

Sequence: VCHHEASEHP LVLSCVDLST WCYVCQAYVH HEDLQDVKNA AHQNKFGEDM

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 85%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against Hdac6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Hdac6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1149 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC6

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Alternative Name: Hdac6

Background: Hdac6 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Hdac6 plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
Alias Symbols: Hd6, Hdac5, Sfc6, mHDA2
Protein Interaction Partner: Hdac11, Ubc, Hsp90ab1, Park2, TARDBP, Vcp, USP47, HDAC6, PLAA, GARS, Tuba1a, Rela, Nfkb1, Mapt,
Protein Size: 1149

Molecular Weight: 126 kDa

Gene ID: 15185

NCBI Accession: NM_010413, NP_034543

UniProt: Q9Z2V5

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling