MafF antibody (N-Term)

Catalog No. ABIN2780877

The Rabbit Polyclonal anti-MafF antibody has been validated for WB. It is suitable to detect MafF in samples from Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse and Rabbit.

Quick Overview for MafF antibody (N-Term) (ABIN2780877)

Target: MafF (MAFF) (Transcription Factor MafF (MAFF))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MafF antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MafF Antibody

Binding Specificity: N-Term

Sequence: SVRELNRHLR GLSAEEVTRL KQRRRTLKNR GYAASCRVKR VCQKEELQKQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against MAFF. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAFF

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 164 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MafF

Target: MafF (MAFF) (Transcription Factor MafF (MAFF))

Alternative Name: MAFF

Background: MAFF is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. MAFF can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. MAFF may also be involved in the cellular stress response.The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: U-MAF, hMafF
Protein Interaction Partner: NFE2L2, PARP1, BACH2, BATF3, MAFF, NFE2L3, NFIL3, NFE2L1, MAFG, FOS, DDIT3, BACH1, ATF3, BATF2, MAFIP, OVOL1, SUMO2, GTF2A1L, HDAC5, PPARG, NR3C1, NFE2, NRF1, PSAP, PRRX1, HOXD12,
Protein Size: 164

Molecular Weight: 18 kDa

Gene ID: 23764

NCBI Accession: NM_152878, NP_690617

UniProt: Q9ULX9

Pathways: Myometrial Relaxation and Contraction