ADNP antibody (N-Term)

Catalog No. ABIN2780972

This Rabbit Polyclonal antibody specifically detects ADNP in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for ADNP antibody (N-Term) (ABIN2780972)

Target: ADNP (Activity-Dependent Neuroprotector Homeobox (ADNP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADNP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADNP Antibody

Binding Specificity: N-Term

Sequence: EDFKQFEPND FYLKNTTWED VGLWDPSLTK NQDYRTKPFC CSACPFSSKF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against ADNP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ADNP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1102 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ADNP

Target: ADNP (Activity-Dependent Neuroprotector Homeobox (ADNP))

Alternative Name: ADNP

Background: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. ADNP is a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. It contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. It is also upregulated in normal proliferative tissues. Finally, ADNP may increase the viability of certain cell types through modulation of p53 activity.Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.
Alias Symbols: ADNP1, KIAA0784
Protein Interaction Partner: UBC, SUMO2, EED, RNF2, BMI1, HDAC1, HDAC11, MYC, CDC27, CBX5, PHGDH, RRS1, EBNA1BP2, SAP18, NFIA, SEPT2, EMD, SIRT7, CBX3, CBX1, MAP1LC3B, ARID1A, SMARCC2, SMARCA4,
Protein Size: 1102

Molecular Weight: 124 kDa

Gene ID: 23394

NCBI Accession: NM_015339, NP_056154

UniProt: Q9H2P0

Pathways: Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process