Polybromo 1 antibody (Middle Region)

Catalog No. ABIN2781052

This Rabbit Polyclonal antibody specifically detects Polybromo 1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio).

Quick Overview for Polybromo 1 antibody (Middle Region) (ABIN2781052)

Target: Polybromo 1 (PBRM1)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Polybromo 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Polybromo 1 Antibody

Binding Specificity: Middle Region

Sequence: SAESNSISKW DQTLAARRRD VHLSKEQESR LPSHWLKSKG AHTTMADALW

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PBRM1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PBRM1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1582 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Polybromo 1

Target: Polybromo 1 (PBRM1)

Alternative Name: PBRM1

Background: PBRM1 is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
Alias Symbols: BAF180, MGC156155, MGC156156, PB1
Protein Interaction Partner: SUMO2, CDC20, UBC, EED, HECW2, ZNF512B, WHSC1, NOTCH1, MAML1, TCHHL1, GTF3C5, APP, CALML5, SIRT7, HIST3H3, SMARCD1, SMARCC2, SMARCAD1, SUMO1, SMARCC1, SMARCB1, SMARCA4, ACTL6A, SMARCE1, CHD7, Bcl7b, ARID2, tat, HIST1H4A, HIST1H3A, HIST2H2BE, HIST2H2AC, AR
Protein Size: 1582

Molecular Weight: 181 kDa

Gene ID: 55193

NCBI Accession: NM_018313, NP_060783