DMAP1 antibody (C-Term)

Catalog No. ABIN2781080

This anti-DMAP1 antibody is a Rabbit Polyclonal antibody detecting DMAP1 in WB. Suitable for Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit and Zebrafish (Danio rerio).

Quick Overview for DMAP1 antibody (C-Term) (ABIN2781080)

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DMAP1 Antibody

Binding Specificity: C-Term

Sequence: PGPASAEPAV TEPGLGPDPK DTIIDVVGAP LTPNSRKRRE SASSSSSVKK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against DMAP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DMAP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 467 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DMAP1

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Alternative Name: DMAP1

Background: DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Alias Symbols: EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1
Protein Interaction Partner: SOX2, UBC, RNF2, HECW2, RUVBL2, SRCAP, CFDP1, RUVBL1, DENR, VPS72, TOMM34, TSG101, H2AFZ, DAXX, SMARCAD1, SUMO2, EPC1, ACTL6A, ACTA1, PPP2R2D, ING3, MORF4L1, BRD8, KAT5, TRRAP, YEATS4, EP400, EPC2, MYC, MAX, ACTG1, ACTB, MRGBP, MORF4L2, MNAT1, HDAC1, tat,
Protein Size: 467

Molecular Weight: 53 kDa

Gene ID: 55929

NCBI Accession: NM_019100, NP_061973

UniProt: Q9NPF5