METTL3 antibody (Middle Region)

Catalog No. ABIN2781087

The Rabbit Polyclonal anti-METTL3 antibody has been validated for WB. It is suitable to detect METTL3 in samples from Human, Rat, Mouse, Dog, Rabbit, Horse, Guinea Pig, Cow, Zebrafish (Danio rerio), Goat and Saccharomyces cerevisiae.

Quick Overview for METTL3 antibody (Middle Region) (ABIN2781087)

Target: METTL3 (Methyltransferase Like 3 (METTL3))

Reactivity: Human, Rat, Mouse, Dog, Rabbit, Horse, Guinea Pig, Cow, Zebrafish (Danio rerio), Goat, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This METTL3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-METTL3 Antibody

Binding Specificity: Middle Region

Sequence: IVAEVRSTSH KPDEIYGMIE RLSPGTRKIE LFGRPHNVQP NWITLGNQLD

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 92%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against METTL3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human METTL3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 580 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for METTL3

Target: METTL3 (Methyltransferase Like 3 (METTL3))

Alternative Name: METTL3

Background: METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
Alias Symbols: M6A, MGC4336, MT-A70, Spo8, IME4
Protein Interaction Partner: UBC, METTL14, UBD,
Protein Size: 580

Molecular Weight: 64 kDa

Gene ID: 56339

NCBI Accession: NM_019852, NP_062826

UniProt: Q86U44