KDM6A antibody (N-Term)

Catalog No. ABIN2781141

The Rabbit Polyclonal anti-KDM6A antibody has been validated for WB. It is suitable to detect KDM6A in samples from Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio) and Pig.

Quick Overview for KDM6A antibody (N-Term) (ABIN2781141)

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM6A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KDM6A Antibody

Binding Specificity: N-Term

Sequence: MKSCGVSLAT AAAAAAAFGD EEKKMAAGKA SGESEEASPS LTAEEREALG

Predicted Reactivity: Cow: 93%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against UTX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UTX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1401 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KDM6A

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Alternative Name: UTX

Background: UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Alias Symbols: DKFZp686A03225, MGC141941, UTX, bA386N14.2, KABUK2
Protein Interaction Partner: KMT2D, WDR5, ASH2L, RBBP5, SMAD9, HIST2H3C, SRF, SMARCA4, GATA4, NKX2-5, TBX5, UBC, HIST1H3A, WDR82, PAXIP1, NCOA6, TLE1, PROSER1, KMT2C, N4BP2, PPP6R3, ZNF281, HIST3H3,
Protein Size: 1401

Molecular Weight: 154 kDa

Gene ID: 7403

NCBI Accession: NM_021140, NP_066963

UniProt: O15550

Pathways: Tube Formation, Warburg Effect