ATP7A antibody (Middle Region)

Catalog No. ABIN2781761

This Rabbit Polyclonal antibody specifically detects ATP7A in WB. It exhibits reactivity toward Human, Rat, Mouse, Dog, Cow, Horse, Guinea Pig, Rabbit, Sheep, Saccharomyces cerevisiae and Zebrafish (Danio rerio).

Quick Overview for ATP7A antibody (Middle Region) (ABIN2781761)

Target: ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))

Reactivity: Human, Rat, Mouse, Dog, Cow, Horse, Guinea Pig, Rabbit, Sheep, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP7A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATP7A Antibody

Binding Specificity: Middle Region

Sequence: MGSAAMAASS VSVVLSSLFL KLYRKPTYES YELPARSQIG QKSPSEISVH

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 93%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against ATP7A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human ATP7A

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATP7A

Target: ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))

Alternative Name: ATP7A

Background: The ATP7A gene encodes the Menkes copper-translocating P-type ATPase, a ubiquitous protein that regulates the absorption of copper in the gastrointestinal tract. Inside cells, this protein has a dual function: it delivers copper to cuproenzymes in the Golgi compartment and effluxes excess copper. The trafficking mechanism and catalytic activity combine to facilitate absorption and intercellular transport of copper. Menkes disease, a systemic copper deficiency disorder, is caused by mutations in the ATP7A gene.
Protein Interaction Partner: ACIN1, UBC, COMMD1, CLU, ATOX1, PDZD11, CP, GLRX,
Protein Size: 503

Molecular Weight: 55 kDa

Gene ID: 538

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process