SGCB antibody (Middle Region)

Catalog No. ABIN2781779

The Rabbit Polyclonal anti-SGCB antibody (ABIN2781779) specifically detects SGCB in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse and Dog samples.

Quick Overview for SGCB antibody (Middle Region) (ABIN2781779)

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGCB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SGCB Antibody

Binding Specificity: Middle Region

Sequence: FSTDYETHEF HLPSGVKSLN VQKASTERIT SNATSDLNIK VDGRAIVRGN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SGCB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SGCB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 318 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SGCB

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Alternative Name: SGCB

Background: SGCB is a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix.The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD, MIM 300377) and syntrophin (SNTA1, MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA, MIM 600119) (Crosbie et al., 2000 [PubMed 10942431]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1235 BC020709.1 1-1235 1236-1833 U31116.1 1257-1854 1834-4229 AK094731.1 47-2442
Alias Symbols: A3b, LGMD2E, SGC
Protein Interaction Partner: UBC, SGCZ, SGCG, SGCD, SGCA,
Protein Size: 318

Molecular Weight: 35 kDa

Gene ID: 6443

NCBI Accession: NM_000232, NP_000223

UniProt: Q16585

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location