LDLR antibody (C-Term)

Catalog No. ABIN2781810

This Rabbit Polyclonal antibody specifically detects LDLR in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit and Horse.

Quick Overview for LDLR antibody (C-Term) (ABIN2781810)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LDLR Antibody

Binding Specificity: C-Term

Sequence: VDSKLHSISS IDVNGGNRKT ILEDEKRLAH PFSLAVFEDK VFWTDIINEA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against LDLR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LDLR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR

Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Alias Symbols: FH, FHC, LDLCQ2
Protein Interaction Partner: PCSK9, UBC, env, MAP4, PDIA3, CREBBP, PDIA4, HSP90B1, HSPA5, CANX, MYLIP, AP1M2, LDLR, SNX17, LDLRAP1, DAB1, PF4, APOE, APOB, LRPAP1, DAB2, CD36,
Protein Size: 682

Molecular Weight: 75 kDa

Gene ID: 3949

NCBI Accession: NM_001195803, NP_001182732

Pathways: Hepatitis C, Lipid Metabolism