PPIB antibody (C-Term)

Catalog No. ABIN2781833

This Rabbit Polyclonal antibody specifically detects PPIB in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit and Zebrafish (Danio rerio).

Quick Overview for PPIB antibody (C-Term) (ABIN2781833)

Target: PPIB (Cyclophilin B (PPIB))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPIB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PPIB Antibody

Binding Specificity: C-Term

Sequence: VVFGKVLEGM EVVRKVESTK TDSRDKPLKD VIIADCGKIE VEKPFAIAKE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PPIB. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PPIB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 216 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPIB

Target: PPIB (Cyclophilin B (PPIB))

Alternative Name: PPIB

Background: PPIB is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
Alias Symbols: CYP-S1, CYPB, MGC14109, MGC2224, SCYLP, OI9
Protein Interaction Partner: BANP, UBQLN1, SGTA, PEX19, UBC, MDM2, DDIT3, WWOX, SUZ12, EED, BMI1, rev, RRM1, PPP5C, PFKP, GAPDH, HECW2, FBXO6, UBD, CFTR, ATP12A, VKORC1, OS9, MAGT1, SUGP1, LSM4, TIMM44, SCO2, ZC3H11A, UBL4A, RBMS1, RANGAP1, PCBP2, P4HB, HSPA5, PDIA3, DHX9, ACAA1, MRP
Protein Size: 216

Molecular Weight: 24 kDa

Gene ID: 5479

NCBI Accession: NM_000942, NP_000933

UniProt: A8K534