FVT1 antibody (N-Term)

Catalog No. ABIN2782154

Product Details anti-FVT1 Antibody

Target: FVT1 (KDSR) (3-Ketodihydrosphingosine Reductase (KDSR))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FVT1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KKEIEMHSIN DKQVVLCISV DVSQDYNQVE NVIKQAQEKL GPVDMLVNCA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against KDSR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human KDSR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FVT1

Target: FVT1 (KDSR) (3-Ketodihydrosphingosine Reductase (KDSR))

Alternative Name: KDSR (KDSR Products)

Background: The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.
Alias Symbols: DHSR, FVT1, SDR35C1
Protein Size: 268

Molecular Weight: 29 kDa

Gene ID: 2531

NCBI Accession: NM_002035, NP_002026

UniProt: B4DMX0