FVT1 antibody (N-Term)

Catalog No. ABIN2782154

The Rabbit Polyclonal anti-FVT1 antibody has been validated for WB. It is suitable to detect FVT1 in samples from Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Dog and Zebrafish (Danio rerio).

Quick Overview for FVT1 antibody (N-Term) (ABIN2782154)

Target: FVT1 (KDSR) (3-Ketodihydrosphingosine Reductase (KDSR))

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FVT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FVT1 Antibody

Binding Specificity: N-Term

Sequence: KKEIEMHSIN DKQVVLCISV DVSQDYNQVE NVIKQAQEKL GPVDMLVNCA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against KDSR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human KDSR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FVT1

Target: FVT1 (KDSR) (3-Ketodihydrosphingosine Reductase (KDSR))

Alternative Name: KDSR

Background: The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.
Alias Symbols: DHSR, FVT1, SDR35C1
Protein Size: 268

Molecular Weight: 29 kDa

Gene ID: 2531

NCBI Accession: NM_002035, NP_002026

UniProt: B4DMX0