Lamin B Receptor antibody (Middle Region)

Catalog No. ABIN2782167

The Rabbit Polyclonal anti-Lamin B Receptor antibody has been validated for WB. It is suitable to detect Lamin B Receptor in samples from Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Dog, Horse, Pig, Rabbit and Saccharomyces cerevisiae.

Quick Overview for Lamin B Receptor antibody (Middle Region) (ABIN2782167)

Target: Lamin B Receptor (LBR)

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Dog, Horse, Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Lamin B Receptor Antibody

Binding Specificity: Middle Region

Sequence: GANSQKNAFR KNPSDPKLAH LKTIHTSTGK NLLVSGWWGF VRHPNYLGDL

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 100%, Yeast: 77%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against LBR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LBR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 615 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Lamin B Receptor

Target: Lamin B Receptor (LBR)

Alternative Name: LBR

Background: The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
Alias Symbols: DHCR14B, LMN2R, MGC9041, PHA
Protein Interaction Partner: UBC, EED, CLK3, HIPK4, LMNA, HNRNPR, EIF4A3, ILF2, HNRNPU, DHX15, DHX9, KCND3, PPP1CC, PPP1CB, PPP1CA, TCF3, ARRB2, SUMO2, HIST2H4A, HIST1H3A, tat, CBX5, SRPK1, FNBP4, AKAP8L, YWHAG, CBX3, LBR, PRM1, LMNB1, MECP2,
Protein Size: 615

Molecular Weight: 71 kDa

Gene ID: 3930

NCBI Accession: NM_002296, NP_002287

UniProt: Q14739