PTPRA antibody (C-Term)

Catalog No. ABIN2782196

The Rabbit Polyclonal anti-PTPRA antibody is suitable to detect PTPRA in samples from Human, Rat, Mouse, Dog, Cow, Rabbit, Zebrafish (Danio rerio), Horse and Guinea Pig. It has been validated for WB.

Quick Overview for PTPRA antibody (C-Term) (ABIN2782196)

Target: PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))

Reactivity: Human, Rat, Mouse, Dog, Cow, Rabbit, Zebrafish (Danio rerio), Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PTPRA Antibody

Binding Specificity: C-Term

Sequence: SRQIRQFHFH GWPEVGIPSD GKGMISIIAA VQKQQQQSGN HPITVHCSAG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PTPRA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PTPRA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 802 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTPRA

Target: PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))

Alternative Name: PTPRA

Background: PTPRA is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRA contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. PTPRA has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
Alias Symbols: HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA
Protein Interaction Partner: UBC, GRB2, CALM1, GABARAPL2, UVRAG, BCAR1, PTPRD, PTPRS, SRC, PTPRF, PRKCD, PTPRM, PTPRA, KCNA2, FYN,
Protein Size: 802

Molecular Weight: 89 kDa

Gene ID: 5786

NCBI Accession: NM_002836, NP_002827

UniProt: P18433