TGFB2 antibody (Middle Region)

Catalog No. ABIN2782223

The Rabbit Polyclonal anti-TGFB2 antibody has been validated for WB. It is suitable to detect TGFB2 in samples from Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Horse, Sheep, Guinea Pig, Zebrafish (Danio rerio).

Quick Overview for TGFB2 antibody (Middle Region) (ABIN2782223)

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Horse, Sheep, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TGFB2 Antibody

Binding Specificity: Middle Region

Sequence: NLVKAEFRVF RLQNPKARVP EQRIELYQIL KSKDLTSPTQ RYIDSKVVKT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against TGFB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TGFB2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 414 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TGFB2

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Alternative Name: TGFB2

Background: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1,7)(q41,p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: MGC116892, TGF-beta2
Protein Interaction Partner: CEBPA, UBC, VASN, PZP, LTBP3, TGFBR3, FMOD, VTN, TGFB3, TGFB2, TGFBR2, TGFBR1, TGFB1, ENG, CTGF, BMP2, APP, TGFBRAP1, DAXX, DCN,
Protein Size: 414

Molecular Weight: 46 kDa

Gene ID: 7042

NCBI Accession: NM_003238, NP_003229

UniProt: P61812

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus