ESRRA antibody (N-Term)

Catalog No. ABIN2782281

This anti-ESRRA antibody is a Rabbit Polyclonal antibody detecting ESRRA in WB. Suitable for Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig and Saccharomyces cerevisiae.

Quick Overview for ESRRA antibody (N-Term) (ABIN2782281)

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESRRA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ESRRA Antibody

Binding Specificity: N-Term

Sequence: KEGVRLDRVR GGRQKYKRRP EVDPLPFPGP FPAGPLAVAG GPRKTAAPVN

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against ESRRA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ESRRA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 423 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ESRRA

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Alternative Name: ESRRA

Background: ESRRA is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes.The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ERR1, ERRa, ERRalpha, ESRL1, NR3B1
Protein Interaction Partner: SUMO2, SUMO3, NSD1, NCOA1, EXOSC6, SMARCD3, ESR1, PIAS4, NXF1, ATXN1, MAP2K5, FUS, ADH5, WDR36, ZNF606, C2CD5, IPO13, TFAP4, Cebpb, ESRRG, PPARGC1A, MACF1, EIF3I, NR0B2, NRIP1, NCOA3, TNNI2, SRC, PROX1, DUT, NR0B1, UBC, PARK2, ZNF658B, SPICE1, KDM3B, DPF1
Protein Size: 423

Molecular Weight: 46 kDa

Gene ID: 2101

NCBI Accession: NM_004451, NP_004442

UniProt: P11474

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha