SBDS antibody (N-Term)

Catalog No. ABIN2782336

This Rabbit Polyclonal antibody specifically detects SBDS in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Zebrafish (Danio rerio), Cow, Guinea Pig and Rabbitand has been mentioned in 1 publication.

Quick Overview for SBDS antibody (N-Term) (ABIN2782336)

Target: SBDS (Shwachman-Bodian-Diamond Syndrome (SBDS))

Reactivity: Human, Mouse, Rat, Dog, Horse, Zebrafish (Danio rerio), Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SBDS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SBDS Antibody

Binding Specificity: N-Term

Sequence: LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against SBDS. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SBDS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 250 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SBDS antibody (ABIN2782336)

Sezgin, Henson, Nihrane, Singh, Wattenberg, Alard, Ellis, Liu: "Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS." in: Pediatric blood & cancer, Vol. 60, Issue 2, pp. 281-6, (2012) (PubMed).

Target Details for SBDS

Target: SBDS (Shwachman-Bodian-Diamond Syndrome (SBDS))

Alternative Name: SBDS

Background: SBDS is a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The protein may function in RNA metabolism. Mutations within its gene are associated with Shwachman-Bodian-Diamond syndrome.This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.
Alias Symbols: CGI-97, FLJ10917, SDS, SWDS
Protein Interaction Partner: SUMO2, TYMS, PNP, IDH1, GOT1, UBC, CHAMP1, MPLKIP, MRPL53, SARNP, SLIRP, SRPRB, ACOT13, SRRM2, TIMM44, TOMM40, UBE4B, SCO2, SNX3, STX7, SF1, VDAC3, TIAL1, SPR, RBMS1, NDUFA7, NDUFA2, IDH3G, STOM, ACAA1, ACD, TERF2IP, POT1, TERF1, CLN3,
Protein Size: 250

Molecular Weight: 28 kDa

Gene ID: 51119

NCBI Accession: NM_016038, NP_057122

UniProt: Q9Y3A5

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly