CBR1 antibody (Middle Region)

Catalog No. ABIN2782364

This anti-CBR1 antibody is a Rabbit Polyclonal antibody detecting CBR1 in WB and IHC. Suitable for Human, Mouse, Rat, Cow, Pig, Rabbit, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio). This Primary Antibody has been cited in 2+ publications.

Quick Overview for CBR1 antibody (Middle Region) (ABIN2782364)

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Reactivity: Human, Mouse, Rat, Cow, Pig, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CBR1 Antibody

Binding Specificity: Middle Region

Sequence: AEVTMKTNFF GTRDVCTELL PLIKPQGRVV NVSSIMSVRA LKSCSPELQQ

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 79%, Rat: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against CBR1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CBR1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 277 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CBR1 antibody (ABIN2782364)

Mitani, Ito, Harada, Nakano, Inui, Ashida, Yamaji: "Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells." in: Journal of nutritional science and vitaminology, Vol. 60, Issue 2, pp. 122-8, (2014) (PubMed).

Lim, Shin, Jo, Jyothi, Nguyen, Choi, Kim, Park, Eun, Yoon, Ha, Kim: "Carbonyl reductase 1 is an essential regulator of skeletal muscle differentiation and regeneration." in: The international journal of biochemistry & cell biology, Vol. 45, Issue 8, pp. 1784-93, (2013) (PubMed).

Target Details for CBR1

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Alternative Name: CBR1

Background: Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues.
Alias Symbols: CBR, hCBR1, SDR21C1
Protein Interaction Partner: MDM2, GRB2, VHL, ESR1, UBC, COPS5, CUL1, UL27, RAD21, Mapk13, UBA5, DDA1, ATG101, PRKAB1, EGFR, ERCC8, MCC,
Protein Size: 277

Molecular Weight: 30 kDa

Gene ID: 873

NCBI Accession: NM_001757, NP_001748

UniProt: P16152