SIK1 antibody (Middle Region)

Catalog No. ABIN2782412

This Rabbit Polyclonal antibody specifically detects SIK1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Dog, Guinea Pig and Zebrafish (Danio rerio)and has been mentioned in 1 publication.

Quick Overview for SIK1 antibody (Middle Region) (ABIN2782412)

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Reactivity: Human, Mouse, Rat, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIK1 Antibody

Binding Specificity: Middle Region

Sequence: TPVLQSQAGL GATVLPPVSF QEGRRASDTS LTQGLKAFRQ QLRKNARTKG

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Sik1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 776 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SIK1 antibody (ABIN2782412)

McTague, Ferguson, Chik, Ho: "The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte." in: Molecular and cellular endocrinology, Vol. 414, pp. 156-67, (2015) (PubMed).

Target Details for SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Alternative Name: Sik1

Background: Sik1 inhibits CREB binding and transcription of cAMP-responsive element (CRE)-dependent genes Cyp11A and Star.
Alias Symbols: Sik, Snf1lk
Protein Size: 776

Molecular Weight: 85 kDa

Gene ID: 59329

NCBI Accession: NM_021693, NP_067725

UniProt: Q9R1U5

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process