SIK1 antibody (N-Term)

Catalog No. ABIN2782413

This Rabbit Polyclonal antibody specifically detects SIK1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Horse, Dog, Guinea Pig, Cow, Pig and Rabbit.

Quick Overview for SIK1 antibody (N-Term) (ABIN2782413)

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Reactivity: Human, Mouse, Rat, Horse, Dog, Guinea Pig, Cow, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SIK1 Antibody

Binding Specificity: N-Term

Sequence: MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 90%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SNF1LK. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SNF1LK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 783 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Alternative Name: SNF1LK

Background: SNF1LK play a transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. It also plays a potential role in G2/M cell cycle regulation. It inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.
Alias Symbols: MSK, SIK, SNF1LK
Protein Interaction Partner: TAB2, MAP3K7, HDAC5, UBC, SUPT5H, RPL3, PRKACA, NMNAT1, STK11, ELAVL1, YWHAZ, PRKAA1, CRTC2, VAPA,
Protein Size: 783

Molecular Weight: 85 kDa

Gene ID: 150094

NCBI Accession: NM_173354, NP_775490

UniProt: P57059

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process