B-Cell Linker antibody (Middle Region)

Catalog No. ABIN2782531

This Rabbit Polyclonal antibody specifically detects B-Cell Linker in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig and Rabbit.

Quick Overview for B-Cell Linker antibody (Middle Region) (ABIN2782531)

Target: B-Cell Linker (BLNK)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This B-Cell Linker antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-B-Cell Linker Antibody

Binding Specificity: Middle Region

Sequence: QYALGRKKNG EEYFGSVAEI IRNHQHSPLV LIDSQNNTKD STRLKYAVKV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against BLNK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BLNK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 456 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for B-Cell Linker

Target: B-Cell Linker (BLNK)

Alternative Name: BLNK

Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological function
Alias Symbols: BASH, BLNK-s, Ly57, MGC111051, SLP-65, SLP65, bca, AGM4, LY57, BLNK-S
Protein Interaction Partner: ERBB2, BTK, GRAP2, SYK, PLCG1, CBL, AIFM1, NCK2, TLN1, MAP2K4, PPP2R2C, PLCG2, MYBPC3, LYN, HSPA4, GRB2, CD79A, CAPZB, CAPZA2, CAPZA1, CLEC17A, WDR81, DOK3, SH3KBP1, CD2AP, HSPH1, VAV3, CMTM3, CBLB, CRKL, MAP4K1, LCP2, NCK1, ITK, PTPN6, VAV1, CD72,
Protein Size: 456

Molecular Weight: 50 kDa

Gene ID: 29760

NCBI Accession: NM_013314, NP_037446

UniProt: Q8WV28

Pathways: BCR Signaling