Myoferlin antibody (C-Term)

Catalog No. ABIN2782797

The Rabbit Polyclonal anti-Myoferlin antibody has been validated for WB. It is suitable to detect Myoferlin in samples from Human, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Rat and Zebrafish (Danio rerio).

Quick Overview for Myoferlin antibody (C-Term) (ABIN2782797)

Target: Myoferlin (MYOF)

Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Myoferlin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Myoferlin Antibody

Binding Specificity: C-Term

Sequence: QTEFRIPPRL IIQIWDNDKF SLDDYLGFLE LDLRHTIIPA KSPEKCRLDM

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against FER1L3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FER1L3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2061 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Myoferlin

Target: Myoferlin (MYOF)

Alternative Name: FER1L3

Background: Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. FER1L3 is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length natures have not been determined.
Alias Symbols: FLJ36571, FLJ90777, MYOF, FER1L3
Protein Interaction Partner: UBC, SUMO2, SUMO3, RPA3, RPA2, RPA1, MATR3, ILF2, ATP6V1B1, CDK2, Kdr, Dnm2, ISG15, SUMO1,
Protein Size: 2061

Molecular Weight: 235 kDa

Gene ID: 26509

NCBI Accession: NM_013451, NP_038479

UniProt: Q9NZM1