CLN6 antibody (Middle Region)

Catalog No. ABIN2782926

This Rabbit Polyclonal antibody specifically detects CLN6 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Guinea Pig, Cow, Rabbit, Sheep and Zebrafish (Danio rerio).

Quick Overview for CLN6 antibody (Middle Region) (ABIN2782926)

Target: CLN6 (Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant (CLN6))

Reactivity: Human, Mouse, Rat, Dog, Horse, Guinea Pig, Cow, Rabbit, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLN6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CLN6 Antibody

Binding Specificity: Middle Region

Sequence: LPRSITYVSI IIFIMGASIH LVGDSVNHRL LFSGYQHHLS VRENPIIKNL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 93%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against CLN6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CLN6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 311 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CLN6

Target: CLN6 (Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant (CLN6))

Alternative Name: CLN6

Background: CLN6 is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely CLN6 involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
Alias Symbols: FLJ20561, HsT18960, nclf, CLN4A
Protein Interaction Partner: RNF2, BMI1, ILK, env, DERL1, VCP, UBC,
Protein Size: 311

Molecular Weight: 36 kDa

Gene ID: 54982

NCBI Accession: NM_017882, NP_060352

UniProt: Q9NWW5

Pathways: Glycosaminoglycan Metabolic Process