ST14 antibody (Middle Region)

Catalog No. ABIN2783208

This Rabbit Polyclonal antibody specifically detects ST14 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Horse, Dog, Pig, Rabbit and Zebrafish (Danio rerio).

Quick Overview for ST14 antibody (Middle Region) (ABIN2783208)

Target: ST14 (Suppression of Tumorigenicity 14 (ST14))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Dog, Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ST14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ST14 Antibody

Binding Specificity: Middle Region

Sequence: RHPGFEATFF QLPRMSSCGG RLRKAQGTFN SPYYPGHYPP NIDCTWNIEV

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 92%, Rat: 93%, Zebrafish: 75%

Characteristics: This is a rabbit polyclonal antibody against ST14. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ST14

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 855 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ST14

Target: ST14 (Suppression of Tumorigenicity 14 (ST14))

Alternative Name: ST14

Background: ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Alias Symbols: HAI, MT-SP1, MTSP-1, MTSP1, PRSS14, SNC19, TADG-15, TADG15, TMPRSS14
Protein Interaction Partner: UBC, RGS16, PDGFC, CDCP1, SPINT1, F2RL1, PLAU, HGF,
Protein Size: 855

Molecular Weight: 95 kDa

Gene ID: 6768

NCBI Accession: NM_021978, NP_068813

UniProt: Q9Y5Y6