Decorin antibody (C-Term)

Catalog No. ABIN2783276

This anti-Decorin antibody is a Rabbit Polyclonal antibody detecting Decorin in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Goat, Horse, Sheep and Zebrafish (Danio rerio).

Quick Overview for Decorin antibody (C-Term) (ABIN2783276)

Target: Decorin (DCN)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Goat, Horse, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Decorin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Decorin Antibody

Binding Specificity: C-Term

Sequence: FCPPGHNTKK ASYSGVSLFS NPVQYWEIQP STFRCVYVRS AIQLGNYK

Predicted Reactivity: Cow: 86%, Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 85%, Sheep: 86%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against DCN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DCN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 359 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Decorin

Target: Decorin (DCN)

Alternative Name: DCN

Background: DCN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. DCN and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.
Alias Symbols: CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Protein Interaction Partner: BRCA1, MET, WISP1, COL4A6, COL4A5, FLNA, TNF, TGFB1, THBS1, MMP3, MMP7, SFTPD, PLA2G2A, AHSG, FN1, FBN1, EGFR, ELN, DPT, C1QA, MMP2, COL14A1, COL5A1, COL1A2, COL1A1, COL4A4, COL4A1, COL4A3, TGFB2, COL6A1,
Protein Size: 359

Molecular Weight: 36 kDa

Gene ID: 1634

NCBI Accession: NM_001920, NP_001911

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process