GMP Synthase antibody (Middle Region)

Catalog No. ABIN2783438

The Rabbit Polyclonal anti-GMP Synthase antibody has been validated for WB. It is suitable to detect GMP Synthase in samples from Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Horse, Rabbit, Cow, Guinea Pig and Pig.

Quick Overview for GMP Synthase antibody (Middle Region) (ABIN2783438)

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Horse, Rabbit, Cow, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GMP Synthase antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GMP Synthase Antibody

Binding Specificity: Middle Region

Sequence: VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against GMPS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GMPS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 693 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GMP Synthase

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Alternative Name: GMPS

Background: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
Alias Symbols: -
Protein Interaction Partner: UBC, SUMO2, SUMO3, TNRC6B, SUMO1, NEDD8, COASY, EFHD2, PPME1, TSTA3, RCN1, RAB1A, PSMD5, PNP, MTAP, ENO2, FBXO6, AGPAT2, VCAM1, ITGA4, FN1, APRT, AHCY, CUL3, SIRT7, SUMO4, USP7, DDA1, PRKAG2, BABAM1, TCEAL1,
Protein Size: 693

Molecular Weight: 77 kDa

Gene ID: 8833

NCBI Accession: NM_003875, NP_003866

UniProt: P49915

Pathways: Ribonucleoside Biosynthetic Process