MAP4K2 antibody (N-Term)

Catalog No. ABIN2783443

This Rabbit Polyclonal antibody specifically detects MAP4K2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Dog, Horse, Pig and Rabbit.

Quick Overview for MAP4K2 antibody (N-Term) (ABIN2783443)

Target: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP4K2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP4K2 Antibody

Binding Specificity: N-Term

Sequence: HLHPMRALML MSKSSFQPPK LRDKTRWTQN FHHFLKLALT KNPKKRPTAE

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 85%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against MAP4K2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAP4K2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 820 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAP4K2

Target: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Alternative Name: MAP4K2

Background: MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Alias Symbols: BL44, GCK, RAB8IP
Protein Interaction Partner: HSP90AA1, UBC, MAP3K11, MAP3K1, POT1, MCM3AP-AS1, NACAD, SNRNP35, PRDX4, SERPINA4, HNRNPA2B1, XRCC6, DEFB1, TRAF2, RAB8A, MAP2K4,
Protein Size: 820

Molecular Weight: 91 kDa

Gene ID: 5871

NCBI Accession: NM_004579, NP_004570

UniProt: Q12851