SULF2 antibody (C-Term)

Catalog No. ABIN2783715

This Rabbit Polyclonal antibody specifically detects SULF2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Pigand has been mentioned in 1 publication.

Quick Overview for SULF2 antibody (C-Term) (ABIN2783715)

Target: SULF2 (Sulfatase 2 (SULF2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SULF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SULF2 Antibody

Binding Specificity: C-Term

Sequence: DVLNQLHVQL MELRSCKGYK QCNPRTRNMD LGLKDGGSYE QYRQFQRRKW

Predicted Reactivity: Cow: 79%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SULF2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SULF2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 870 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SULF2 antibody (ABIN2783715)

Uchimura, Morimoto-Tomita, Bistrup, Li, Lyon, Gallagher, Werb, Rosen: "HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1." in: BMC biochemistry, Vol. 7, pp. 2, (2006) (PubMed).

Target Details for SULF2

Target: SULF2 (Sulfatase 2 (SULF2))

Alternative Name: SULF2

Background: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM].
Alias Symbols: DKFZp313E091, FLJ90554, HSULF-2, KIAA1247, MGC126411
Protein Interaction Partner: MYC, UBC,
Protein Size: 870

Molecular Weight: 98 kDa

Gene ID: 55959

NCBI Accession: NM_018837, NP_061325

UniProt: Q8IWU5