PCDHGC4 antibody (N-Term)

Catalog No. ABIN2783728

The Rabbit Polyclonal anti-PCDHGC4 antibody has been validated for WB and IHC. It is suitable to detect PCDHGC4 in samples from Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Pig and Rabbit.

Quick Overview for PCDHGC4 antibody (N-Term) (ABIN2783728)

Target: PCDHGC4 (Protocadherin gamma Subfamily C, 4 (PCDHGC4))

Reactivity: Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PCDHGC4 Antibody

Binding Specificity: N-Term

Sequence: VKKRSDGSLV PELLLEKPLD REKQSDYRLV LTAVDGGNPP RSGTAELRVS

Predicted Reactivity: Horse: 100%, Human: 100%, Mouse: 100%, Pig: 91%, Rabbit: 79%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHGC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHGC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 938 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHGC4

Target: PCDHGC4 (Protocadherin gamma Subfamily C, 4 (PCDHGC4))

Alternative Name: PCDHGC4

Background: PCDHGC4 is a single-pass type I membrane protein. It contains 6 cadherin domains.PCDHGC4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Alias Symbols: MGC119489, PCDH-GAMMA-C4
Protein Size: 938

Molecular Weight: 98 kDa

Gene ID: 56098

NCBI Accession: NM_018928, NP_061751

UniProt: Q9Y5F7