TMCO1 antibody (C-Term)

Catalog No. ABIN2783742

The Rabbit Polyclonal anti-TMCO1 antibody has been validated for WB. It is suitable to detect TMCO1 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio). There are 2+ publications available.

Quick Overview for TMCO1 antibody (C-Term) (ABIN2783742)

Target: TMCO1 (Transmembrane and Coiled-Coil Domains 1 (TMCO1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMCO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TMCO1 Antibody

Binding Specificity: C-Term

Sequence: CSFIFLYILC TMSIRQNIQK ILGLAPSRAA TKQAGGFLGP PPPSGKFS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against TMCO1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TMCO1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 188 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TMCO1 antibody (ABIN2783742)

Sharma, Burdon, Chidlow, Klebe, Crawford, Dimasi, Dave, Martin, Javadiyan, Wood, Casson, Danoy, Griggs, Hewitt, Landers, Mitchell, Mackey, Craig: "Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterization of the protein in the eye." in: Investigative ophthalmology & visual science, Vol. 53, Issue 8, pp. 4917-25, (2012) (PubMed).

Burdon, Macgregor, Hewitt, Sharma, Chidlow, Mills, Danoy, Casson, Viswanathan, Liu, Landers, Henders, Wood, Souzeau, Crawford, Leo, Wang, Rochtchina, Nyholt, Martin, Montgomery, Mitchell, Brown et al.: "Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. ..." in: Nature genetics, Vol. 43, Issue 6, pp. 574-8, (2011) (PubMed).

Target Details for TMCO1

Target: TMCO1 (Transmembrane and Coiled-Coil Domains 1 (TMCO1))

Alternative Name: TMCO1

Background: TMCO1 belongs to the TMCO1 family. The exact function of TMCO1 remains unknown.
Alias Symbols: HP10122, PCIA3, PNAS-136, RP11-466F5.7, TMCC4
Protein Interaction Partner: UBC, FBXO6, SERINC1, LAMTOR3, SRSF5, RPS10, ABCC1, ELAVL1, UNC93B1,
Protein Size: 188

Molecular Weight: 21 kDa

Gene ID: 54499

NCBI Accession: NM_019026, NP_061899

UniProt: Q9UM00