HES5 antibody (Middle Region)

Catalog No. ABIN2784162

Product Details anti-HES5 Antibody

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AASDTQMKLL YHFQRPPAAP AAPAKEPKAP GAAPPPALSA KATAAAAAAH

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 85%, Human: 100%, Mouse: 88%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HES5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HES5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 166 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HES5

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Alternative Name: HES5 (HES5 Products)

Background: This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
Alias Symbols: bHLHb38
Protein Interaction Partner: STAT3, JAK2, UBC,
Protein Size: 166

Molecular Weight: 18 kDa

Gene ID: 388585

NCBI Accession: NM_001010926, NP_001010926

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation