Ataxin 3 antibody (N-Term)

Catalog No. ABIN2784210

The Rabbit Polyclonal anti-Ataxin 3 antibody has been validated for WB. It is suitable to detect Ataxin 3 in samples from Human, Mouse, Rat, Cow, Sheep, Horse, Rabbit, Guinea Pig, Dog and Zebrafish (Danio rerio).

Quick Overview for Ataxin 3 antibody (N-Term) (ABIN2784210)

Target: Ataxin 3 (ATXN3)

Reactivity: Human, Mouse, Rat, Cow, Sheep, Horse, Rabbit, Guinea Pig, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Ataxin 3 Antibody

Binding Specificity: N-Term

Sequence: SIAHQLDEEE RMRMAEGGVT SEDYRTFLQQ PSGNMDDSGF FSIQVISNAL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against ATXN3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATXN3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 361 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ataxin 3

Target: Ataxin 3 (ATXN3)

Alternative Name: ATXN3

Background: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: AT3, ATX3, JOS, MJD, MJD1, SCA3
Protein Interaction Partner: UBC, NEDD8, ATXN3, TRIM63, SQSTM1, VCP, ITCH, PARK2, MGRN1, TUBB, HDAC6, TUBA1A, ELC1, ELA1, SYVN1, BAG3, BCL2L1, STUB1, SUMO1, APP, RFFL, TRIM55, SPRTN, PJA1, TRIM54, USP21, UBE2L3, ARHGDIA, ASIC1, RAD23B, RAD23A, ARHGAP19, C16orf70, TEX11, PICK1, GSK3B,
Protein Size: 361

Molecular Weight: 41 kDa

Gene ID: 4287

NCBI Accession: NM_004993, NP_004984

UniProt: P54252