ING1 antibody (N-Term)

Catalog No. ABIN2784212

The Rabbit Polyclonal anti-ING1 antibody has been validated for WB. It is suitable to detect ING1 in samples from Human.

Quick Overview for ING1 antibody (N-Term) (ABIN2784212)

Target: ING1 (Inhibitor of Growth Family, Member 1 (ING1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ING1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ING1 Antibody

Binding Specificity: N-Term

Sequence: SPAERLVAEA DEGGPSAITG MGLCFRCLLF SFSGRSGVEG GRVDLNVFGS

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ING1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ING1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 422 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ING1

Target: ING1 (Inhibitor of Growth Family, Member 1 (ING1))

Alternative Name: ING1

Background: ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of ING1 gene have been detected in various cancers.
Alias Symbols: p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
Protein Interaction Partner: SIRT1, SIRT2, UBC, HDAC1, KIAA0101, PCNA, RBP1, RBBP7, RBBP4, HDAC2, BRMS1L, SIN3A, BRMS1, SAP30, ELAVL1, SMURF1, COPS2, NQO1, HIST2H3C, MRGBP, YWHAZ, YWHAH, YWHAG, YWHAE, YWHAB, KPNA2, KPNB1, YWHAQ, SFN, ESR1, LMNA, CDKN2A, TP53, KAT2B, DMAP1, EP300, HHT
Protein Size: 422

Molecular Weight: 47 kDa

Gene ID: 3621

NCBI Accession: NM_005537, NP_005528

UniProt: Q9UK53

Pathways: Protein targeting to Nucleus, Autophagy