HIST2H2AC antibody (Middle Region)

Catalog No. ABIN2784540

The Rabbit Polyclonal anti-HIST2H2AC antibody has been validated for WB. It is suitable to detect HIST2H2AC in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig and Rabbit.

Quick Overview for HIST2H2AC antibody (Middle Region) (ABIN2784540)

Target: HIST2H2AC (Histone Cluster 2, H2ac (HIST2H2AC))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIST2H2AC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HIST2H2AC Antibody

Binding Specificity: Middle Region

Sequence: IPRHLQLAIR NDEELNKLLG KVTIAQGGVL PNIQAVLLPK KTESHKAKSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HIST2H2AC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HIST2H2AC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 129 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HIST2H2AC

Target: HIST2H2AC (Histone Cluster 2, H2ac (HIST2H2AC))

Alternative Name: HIST2H2AC

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. HIST2H2AC is a member of the histone H2A family.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: H2A, H2A-GL101, H2A/q, H2AFQ, MGC74460
Protein Interaction Partner: BAP1, UBC, RNF2, INO80, UIMC1, RAD6, HDAC2, USP16, AURKB, NEDD8, CUL4A, USP15, SART3, HIST2H2BE, POLR2C, RNF168, HCVgp1, PRAME, RNF8, CRP, CENPA, HIST1H3B, EP300, KAT2A, BRCA1, BARD1, RBBP7, RBBP4, HAT1, ATXN7L3, USP22, MECP2, CHFR, DDB2, HIST1H4A, HIST1H
Protein Size: 129

Molecular Weight: 14 kDa

Gene ID: 8338

NCBI Accession: NM_003517, NP_003508

UniProt: Q16777