PACS2 antibody (Middle Region)

Catalog No. ABIN2784562

This Rabbit Polyclonal antibody specifically detects PACS2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio).

Quick Overview for PACS2 antibody (Middle Region) (ABIN2784562)

Target: PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PACS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PACS2 Antibody

Binding Specificity: Middle Region

Sequence: AHQLPIAEAM LTYKQKSPDE ESSQKFIPFV GVVKVGIVEP SSATSGDSDD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PACS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PACS2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 889 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PACS2

Target: PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))

Alternative Name: PACS2

Background: PACS2 is the multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer,PACS2 translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Alias Symbols: FLJ25488, KIAA0602, PACS1L, PACS-2
Protein Interaction Partner: UBC, TRAF2, BIRC3, BIRC2, PKD2, BID,
Protein Size: 889

Molecular Weight: 98 kDa

Gene ID: 23241

NCBI Accession: NM_015197, NP_056012

UniProt: Q86VP3