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ABAT antibody (Middle Region)

This Rabbit Polyclonal antibody specifically detects ABAT in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Saccharomyces cerevisiae.
Catalog No. ABIN2784615

Quick Overview for ABAT antibody (Middle Region) (ABIN2784615)

Target

See all ABAT Antibodies
ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Reactivity

  • 48
  • 32
  • 30
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host

  • 45
  • 5
Rabbit

Clonality

  • 43
  • 7
Polyclonal

Conjugate

  • 30
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This ABAT antibody is un-conjugated

Application

  • 42
  • 19
  • 13
  • 13
  • 10
  • 10
  • 8
  • 8
  • 5
  • 4
  • 1
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 15
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequence

    IIVEPIQSEG GDNHASDDFF RKLRDIARKH GCAFLVDEVQ TGGGCTGKFW

    Predicted Reactivity

    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 86%

    Characteristics

    This is a rabbit polyclonal antibody against ABAT. It was validated on Western Blot using a cell lysate as a positive control.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human ABAT
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator.

    Comment

    Antigen size: 500 AA

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    ABAT (4-Aminobutyrate Aminotransferase (ABAT))

    Alternative Name

    ABAT

    Background

    4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
    Alias Symbols: GABA-AT, GABAT, NPD009
    Protein Interaction Partner: LGR4, BAG3, ALDH5A1, ABAT,
    Protein Size: 500

    Molecular Weight

    55 kDa

    Gene ID

    18

    NCBI Accession

    NM_020686, NP_065737

    UniProt

    P80404

    Pathways

    Monocarboxylic Acid Catabolic Process
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