Adrenomedullin antibody (C-Term)

Catalog No. ABIN2784687

This anti-Adrenomedullin antibody is a Rabbit Polyclonal antibody detecting Adrenomedullin in WB. Suitable for Human and Rabbit.

Quick Overview for Adrenomedullin antibody (C-Term) (ABIN2784687)

Target: Adrenomedullin (ADM)

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adrenomedullin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Adrenomedullin Antibody

Binding Specificity: C-Term

Sequence: VAPRSKISPQ GYGRRRRRSL PEAGPGRTLV SSKPQAHGAP APPSGSAPHF

Predicted Reactivity: Human: 100%, Rabbit: 91%

Characteristics: This is a rabbit polyclonal antibody against ADM. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 185 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Adrenomedullin

Target: Adrenomedullin (ADM)

Alternative Name: ADM

Target Type: Hormone

Background: Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.
Alias Symbols: AM
Protein Interaction Partner: CALCRL, EDN1, CFH, MME, ADM,
Protein Size: 185

Molecular Weight: 20 kDa

Gene ID: 133

NCBI Accession: NM_001124, NP_001115

UniProt: P35318

Pathways: Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation