CA5B antibody (N-Term)

Catalog No. ABIN2784871

This Rabbit Polyclonal antibody specifically detects CA5B in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Pig, Rabbit, Cow, Dog, Guinea Pig and Sheep.

Quick Overview for CA5B antibody (N-Term) (ABIN2784871)

Target: CA5B (Carbonic Anhydrase VB, Mitochondrial (CA5B))

Reactivity: Human, Mouse, Rat, Horse, Pig, Rabbit, Cow, Dog, Guinea Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CA5B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CA5B Antibody

Binding Specificity: N-Term

Sequence: WRDSVYDPGL KPLTISYDPA TCLHVWNNGY SFLVEFEDST DKSVIKGGPL

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against CA5B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CA5B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 317 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CA5B

Target: CA5B (Carbonic Anhydrase VB, Mitochondrial (CA5B))

Alternative Name: CA5B

Background: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.
Alias Symbols: CA-VB, MGC39962
Protein Interaction Partner: ELAVL1,
Protein Size: 317

Molecular Weight: 33 kDa

Gene ID: 11238

NCBI Accession: NM_007220, NP_009151

UniProt: Q9Y2D0