EXOC3 antibody (Middle Region)

Catalog No. ABIN2784880

Product Details anti-EXOC3 Antibody

Target: EXOC3 (Exocyst Complex Component 3 (EXOC3))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LERTVTTRIE GTQADTRESD KMWLVRHLEI IRKYVLDDLI VAKNLMVQCF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against EXOC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EXOC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 745 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EXOC3

Target: EXOC3 (Exocyst Complex Component 3 (EXOC3))

Alternative Name: EXOC3 (EXOC3 Products)

Background: EXOC3 is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.
Alias Symbols: SEC6, SEC6L1, Sec6p
Protein Interaction Partner: UBC, INPP5K, PRPF19, KIAA0907, EGFR, EXOC4, BUB3, MLH1, EXOC8, EXOC2, EXOC6, EXOC5, APP, MYO5A, Poc1b, RALA, GRIN2B, DLG3,
Protein Size: 745

Molecular Weight: 85 kDa

Gene ID: 11336

NCBI Accession: NM_007277, NP_009208

UniProt: Q6P2E8

Pathways: Peptide Hormone Metabolism, Synaptic Vesicle Exocytosis