CRY2 antibody (N-Term)

Catalog No. ABIN2784909

This anti-CRY2 antibody is a Rabbit Polyclonal antibody detecting CRY2 in WB and IHC. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep and Zebrafish (Danio rerio). This Primary Antibody has been cited in 1 publication.

Quick Overview for CRY2 antibody (N-Term) (ABIN2784909)

Target: CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRY2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CRY2 Antibody

Binding Specificity: N-Term

Sequence: IELNGQKPPL TYKRFQAIIS RMELPKKPVG LVTSQQMESC RAEIQENHDE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against CRY2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CRY2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 593 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CRY2 antibody (ABIN2784909)

Currie, Doherty, Sillar: "Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 21, pp. 6053-8, (2016) (PubMed).

Target Details for CRY2

Target: CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))

Alternative Name: CRY2

Background: CRY2 is a blue light-dependent regulator of the circadian feedback loop.CRY2 inhibits CLOCK NPAS2-ARNTL E box-mediated transcription. CRY2 acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity.CRY2 has no photolyase activity. CRY2 is capable of translocating circadian clock core proteins such as PER proteins to the nucleus.CRY2 may inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
Alias Symbols: FLJ10332, HCRY2, KIAA0658, PHLL2
Protein Interaction Partner: MTUS2, PDE9A, CTBP1, UBC, FBXL3, FBXL21, BTRC, CUL1, SKP1, ATXN1, Csnk1e, PER3, PER2, PER1, PPP5C, TTC1, CRY2, TIMELESS,
Protein Size: 593

Molecular Weight: 67 kDa

Gene ID: 1408

NCBI Accession: NM_021117, NP_066940

UniProt: Q49AN0

Pathways: Response to Water Deprivation, Protein targeting to Nucleus