IL-24 antibody (C-Term)

Catalog No. ABIN2785371

This anti-IL-24 antibody is a Rabbit Polyclonal antibody detecting IL-24 in WB. Suitable for Human, Rat, Mouse, Dog and Horse.

Quick Overview for IL-24 antibody (C-Term) (ABIN2785371)

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Reactivity: Human, Rat, Mouse, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-24 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL-24 Antibody

Binding Specificity: C-Term

Sequence: STLANNFVLI VSQLQPSQEN EMFSIRDSAH RRFLLFRRAF KQLDVEAALT

Predicted Reactivity: Dog: 77%, Horse: 85%, Human: 100%, Mouse: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against IL24. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of IL24

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 207 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL-24

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Alternative Name: IL24

Background: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27 kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: C49A, FISP, IL-24, IL10B, MDA7, Mob-5, ST16, mda-7, MOB5
Protein Interaction Partner: DCD, RARG, CCR5, CLU, UBC, IL20RA,
Protein Size: 207

Molecular Weight: 22 kDa

Gene ID: 11009

NCBI Accession: NM_001185156, NP_001172085

UniProt: Q53XZ7

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagy