FGFR1OP antibody (Middle Region)

Catalog No. ABIN2785510

The Rabbit Polyclonal anti-FGFR1OP antibody has been validated for WB and IHC. It is suitable to detect FGFR1OP in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Horse and Guinea Pig.

Quick Overview for FGFR1OP antibody (Middle Region) (ABIN2785510)

Target: FGFR1OP (FGFR1 Oncogene Partner (FGFR1OP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR1OP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FGFR1OP Antibody

Binding Specificity: Middle Region

Sequence: LSDVHSPPKS PEGKTSAQTT PSKIPRYKGQ GKKKTSGQKA GDKKANDEAN

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 77%, Rabbit: 85%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against FGFR1OP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FGFR1OP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 379 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FGFR1OP

Target: FGFR1OP (FGFR1 Oncogene Partner (FGFR1OP))

Alternative Name: FGFR1OP

Background: FGFR1OP is a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t (6,8)(q27,p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage.This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6,8)(q27,p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
Alias Symbols: FOP
Protein Interaction Partner: CEP19, VASP, BRCA1, WRNIP1, ABL1, UBC, NAGK, FGFR1OP, CEP350, PACS1, PPP2R1A, PPP2R1B, PPP2CB, PPP2CA,
Protein Size: 379

Molecular Weight: 42 kDa

Gene ID: 11116

NCBI Accession: NM_194429, NP_919410

UniProt: O95684

Pathways: M Phase, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome