ACADS antibody (Middle Region)

Catalog No. ABIN2785627

This Rabbit Polyclonal antibody specifically detects ACADS in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Cow and Dog.It has been mentioned in 1 publication

Quick Overview for ACADS antibody (Middle Region) (ABIN2785627)

Target: ACADS (Acads) (Acyl-CoA Dehydrogenase, C-2 To C-3 Short Chain (Acads))

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACADS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACADS Antibody

Binding Specificity: Middle Region

Purpose: ACADS Antibody - middle region

Sequence: FTSGDKIGCF ALSEPGNGSD AGAASTTARA EGDSWVLNGT KAWITNAWEA

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against ACADS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ACADS

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54276-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ACADS antibody (ABIN2785627)

Tein, Elpeleg, Ben-Zeev, Korman, Lossos, Lev, Lerman-Sagie, Leshinsky-Silver, Vockley, Berry, Lamhonwah, Matern, Roe, Gregersen: "Short-chain acyl-CoA dehydrogenase gene mutation (c.319C>T) presents with clinical heterogeneity and is candidate founder mutation in individuals of Ashkenazi Jewish origin." in: Molecular genetics and metabolism, Vol. 93, Issue 2, pp. 179-89, (2008) (PubMed).

Target Details for ACADS

Target: ACADS (Acads) (Acyl-CoA Dehydrogenase, C-2 To C-3 Short Chain (Acads))

Alternative Name: ACADS

Background:

Background Information: ACADS is a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency. This gene encodes a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Acyl-CoA dehydrogenase, C-2 to C-3 short chain

Alternative Symbols: SCAD, ACAD3

Protein Name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Molecular Weight: 42kDa

Gene ID: 35

NCBI Accession: NP_000008

UniProt: P16219

Pathways: Monocarboxylic Acid Catabolic Process