Gelsolin antibody (C-Term)

Catalog No. ABIN2785642

This Rabbit Polyclonal antibody specifically detects Gelsolin in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse, Cow, Rabbit, Dog, Horse, Sheep, Zebrafish (Danio rerio) and Guinea Pigand has been mentioned in 1 publication.

Quick Overview for Gelsolin antibody (C-Term) (ABIN2785642)

Target: Gelsolin (GSN)

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Dog, Horse, Sheep, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gelsolin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Gelsolin Antibody

Binding Specificity: C-Term

Sequence: KPMIIYKGGT SREGGQTAPA STRLFQVRAN SAGATRAVEV LPKAGALNSN

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against GSN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GSN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 782 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Gelsolin antibody (ABIN2785642)

Shokouhi, Khosroshahi: "Ardalan-Shoja-Kiuru syndrome--hereditary gelsolin amyloidosis plus retinitis pigmentosa." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 23, Issue 3, pp. 1071; author reply 1071-2, (2008) (PubMed).

Target Details for Gelsolin

Target: Gelsolin (GSN)

Alternative Name: GSN

Background: GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF).The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: DKFZp313L0718, ADF, AGEL
Protein Interaction Partner: ITCH, CFLAR, TP53, UBC, CASP3, UBD, FN1, MPG, ESR1, ALB, SDHB, ACTA1, MDM2, UBE2Q2, FBXO25, ARRB2, ARRB1, AR, PSMD4, TNIK, CLIC5, TOM1L1, ACTN4, VDAC1, BCAR1, PXN, LIMK2, VASP, PIK3CG, PTK2B, FHIT, VCL, CSK, APP, ACTB, ACTG1, PLCG1, SRC, PTPN12, PTK2, PIK
Protein Size: 782

Molecular Weight: 83 kDa

Gene ID: 2934

NCBI Accession: NM_000177, NP_000168

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy