FKBP3 antibody (C-Term)

Catalog No. ABIN2785798

This Rabbit Polyclonal antibody specifically detects FKBP3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for FKBP3 antibody (C-Term) (ABIN2785798)

Target: FKBP3 (FK506 Binding Protein 3, 25kDa (FKBP3))

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FKBP3 Antibody

Binding Specificity: C-Term

Sequence: EALLTMSKGE KARLEIEPEW AYGKKGQPDA KIPPNAKLTF EVELVDID

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against FKBP3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FKBP3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 224 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FKBP3

Target: FKBP3 (FK506 Binding Protein 3, 25kDa (FKBP3))

Alternative Name: FKBP3

Background: FKBP3 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Alias Symbols: FKBP-25, PPIase, FKBP-3, FKBP25
Protein Interaction Partner: UBC, EDC4, IGF2BP3, SYNCRIP, SEC16A, EIF2B2, EIF2B3, DYNLL1, RFC4, YBX1, NMT1, KRT18, ILF2, HNRNPU, HNRNPA2B1, DDX1, ABCF1, MAP1S, C14orf166, DIMT1, NELFB, SRPK1, FBXO25, BARD1, MYH10, PACSIN3, LRRFIP1, TIMELESS, Nedd4, NEDD4L, CALM1, HDAC2, HDAC1, YY1, C
Protein Size: 224

Molecular Weight: 25 kDa

Gene ID: 2287

NCBI Accession: NM_002013, NP_002004

UniProt: Q00688