FTH1 antibody (N-Term)

Catalog No. ABIN2785802

This Rabbit Polyclonal antibody specifically detects FTH1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Sheep, Pig, Dog, Rabbit, Horse, Cow, Guinea Pig and Goat.

Quick Overview for FTH1 antibody (N-Term) (ABIN2785802)

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Reactivity: Human, Mouse, Rat, Sheep, Pig, Dog, Rabbit, Horse, Cow, Guinea Pig, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FTH1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FTH1 Antibody

Binding Specificity: N-Term

Sequence: MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against FTH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FTH1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 183 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FTH1

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Alternative Name: FTH1

Background: FTH1 is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases.
Alias Symbols: FTH, FTHL6, MGC104426, PIG15, PLIF, FHC
Protein Interaction Partner: SDCBP, FTL, FTH1, WDYHV1, CEP57, AURKB, TP53, AURKA, ASB15, ASB16, SUPT16H, SET, MAPK9, MAX, IGSF8, TICAM2, HCVgp1, PIAS4, CDC16, YWHAE, SOX5, MYL3, LBP, KPNA2, GRB2, DAXX, CSNK2B, CDC25A, ATP6V1B1, CD99, SPP1, TRAF4, SUMO2, UBC, Cep55, Trim28, NR1I3, NR3
Protein Size: 183

Molecular Weight: 21 kDa

Gene ID: 2495

NCBI Accession: NM_002032, NP_002023

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis