SENP1 antibody (Middle Region)

Catalog No. ABIN2786045

This Rabbit Polyclonal antibody specifically detects SENP1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for SENP1 antibody (Middle Region) (ABIN2786045)

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SENP1 Antibody

Binding Specificity: Middle Region

Sequence: PQQMNGSDCG MFACKYADCI TKDRPINFTQ QHMPYFRKRM VWEILHRKLL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against SENP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SENP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 643 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SENP1

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Alternative Name: SENP1

Background: The covalent modification of proteins by the small ubiquitin-like protein SUMO is implicated in the regulation of nucleocytoplasmic transport, genomic stability, gene transcription, and other processes. Sumoylation is catalyzed on target lysine residues by a multienzyme process and is reversed by desumoylating enzymes such as SENP1.
Alias Symbols: SuPr-2
Protein Interaction Partner: USP25, RABGAP1, SUMO1, TP53, SP100, SUMO2, SUMO3, RANGAP1, PRDM1, BAG3, LMNA, APP, UBD, U90, HIPK2, ISG15, RANBP2, HDAC2, ELAVL1, UBC, GCM1, RUVBL2, HDAC1, PARP1, HDAC4, KCNK1, SENP1, SP3,
Protein Size: 643

Molecular Weight: 73 kDa

Gene ID: 29843

NCBI Accession: NM_014554, NP_055369

Pathways: Positive Regulation of Endopeptidase Activity