GOPC antibody (Middle Region)

Catalog No. ABIN2786579

This Rabbit Polyclonal antibody specifically detects GOPC in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig and Horse.

Quick Overview for GOPC antibody (Middle Region) (ABIN2786579)

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GOPC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GOPC Antibody

Binding Specificity: Middle Region

Sequence: RNDLKRPMQA PPGHDQDSLK KSQGVGPIRK VLLLKEDHEG LGISITGGKE

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GOPC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GOPC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 454 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GOPC

Target: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Alternative Name: GOPC

Background: GOPC plays a role in intracellular protein trafficking and degradation. GOPC may regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. GOPC may also regulate the intracellular trafficking of the ADR1B receptor. GOPC may play a role in autophagy. Overexpression of GOPC results in CFTR intracellular retention and degradation in the lysosomes.PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM].
Alias Symbols: CAL, FIG, GOPC1, PIST, dJ94G16.2
Protein Interaction Partner: BATF, SSNA1, VTN, MYLK, HCK, FOSL2, DPYD, RPL13AP17, C17orf67, ZSCAN1, LCLAT1, FAM9B, ZBTB49, ZNF564, SPATA8, RNF183, MORN4, MYOCD, MUM1, ZNF587, SLC25A18, CCDC102B, AKIRIN1, MRPL1, SEMA4G, RNF220, FAM90A1, PID1, ZNF581, CERCAM, RHOQ, PARK7, STARD3, HSF1,
Protein Size: 454

Molecular Weight: 50 kDa

Gene ID: 57120

NCBI Accession: NM_001017408, NP_001017408

UniProt: Q9HD26

Pathways: Maintenance of Protein Location, Asymmetric Protein Localization