Sec8 antibody (N-Term)

Catalog No. ABIN2786600

The Rabbit Polyclonal anti-Sec8 antibody has been validated for WB. It is suitable to detect Sec8 in samples from Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Dog and Zebrafish (Danio rerio).

Quick Overview for Sec8 antibody (N-Term) (ABIN2786600)

Target: Sec8 (EXOC4) (Exocyst Complex Component 4 (EXOC4))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sec8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Sec8 Antibody

Binding Specificity: N-Term

Sequence: MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against EXOC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EXOC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 473 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Sec8

Target: Sec8 (EXOC4) (Exocyst Complex Component 4 (EXOC4))

Alternative Name: EXOC4

Background: The specific function of this protein remains unknown.The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: MGC27170, REC8, SEC8, SEC8L1, Sec8p
Protein Interaction Partner: SUMO2, UBC, EXOC2, EXOC7, ATG5, ATG12, BECN1, EXOC8, EGFR, EXOC1, EXOC3, nef, IQCB1, EXOC5, UBD, MYO5A, DTNBP1, CEP63, DISC1, Poc1b, GTF2E2, DLGAP4, DLG3, RALA, GRIN2B, DLG4, MYC,
Protein Size: 473

Molecular Weight: 54 kDa

Gene ID: 60412

NCBI Accession: NM_001037126, NP_001032203

UniProt: Q8TAR2

Pathways: Peptide Hormone Metabolism, Synaptic Vesicle Exocytosis