PDE4D antibody (C-Term)

Catalog No. ABIN2786831

This Rabbit Polyclonal antibody specifically detects PDE4D in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Cow, Dog, Rabbit, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for PDE4D antibody (C-Term) (ABIN2786831)

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4D antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE4D Antibody

Binding Specificity: C-Term

Sequence: FQFELTLEED GESDTEKDSG SQVEEDTSCS DSKTLCTQDS ESTEIPLDEQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PDE4D. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDE4D

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE4D

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Alternative Name: PDE4D

Background: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Protein Interaction Partner: MAGEA6, GOLGA8F, GOLGA8EP, COIL, TRAF1, ZBTB1, HDGFRP2, BIN1, MAPK1, PIAS4, PRKACA, UBC, SRC, SPTBN1, PIK3CA, LYN, GRB2, FYN, ARRB2, ARRB1, ABL1, APP, PAFAH1B1, CDK2, PPP3R1, PPP3CB, PPP3CA, GSK3B, CSNK1A1, ITSN1, SUMO2, GNB2L1, MDM2, Bub1, PDE4DIP, AKAP6
Protein Size: 507

Molecular Weight: 55 kDa

Gene ID: 5144

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling